After two rounds of design, we obtained 4e with an IC50 of 3.0 0.8 M, which is one of the most potent TNF- small molecule inhibitors reported so far. TNF- inhibitor, EJMC-1 with modest activity. Here, we optimized this compound by shape screen and rational design. In the first round, we screened commercial compound library […]
performed KIR genetic analysis. CD45RA+ (CCR7CCD45RA+) cells in the CD8+ T?cell compartment (24.1 14.4 versus 32.3 16.9, p?=?0.014), whereas no significant changes were observed for any of the other CD8 T?cell subsets studied (Figures S1A and S1B). Interestingly, the accumulation of mature CD8 T?cells was particularly visible in young and middle-age individuals (17.8 9.6 versus […]