Lack of surface lipoprotein to endocytosis was prevented using hypertonic sucrose (49). that contain either apoE or apoB100 (1, 2). The LDLR is principally responsible for the uptake of two lipoproteins: LDL, which the LDLR binds in an FTI 276 apoB100-dependent manner, and VLDL remnants, which the LDLR binds in an apoE-dependent manner (3, 4). […]