In the oral cavity lymphomas of the NHL type occurs as a primary disease or in conjunction with disseminated disease. of non-Hodgkins B-cell lymphoma with three variants namely endemic, sporadic, and immunodeficiency-associated types. It is endemic in Africa and sporadic in other parts of the world. We report a rare case of sporadic BL presenting as generalized gingival enlargement. The purpose of this case report is to illustrate the fact that gingival enlargements may be caused by any benign non-neoplastic lesions or aggressive malignancies like BL and bespeaks the need for prompt recognition and life-saving referral by the dental practitioner. == INTRODUCTION == Lymphomas are malignant neoplasms of lymphocyte cell lines and ranks second to squamous cell carcinoma in frequency of occurrence in head and neck. They are of two types: Hodgkins (HL) and Non-Hodgkins (NHL). HL often presents as a nodal disease with predilection for head and mediastinal nodes. NHL are heterogenous group of neoplasms arising primarily within the lymph nodes but up to 24%-40% cases occur in extra nodal sites such as gastrointestinal tract, skin, bone and Waldeyers ring[1]. Burkitts lymphoma (BL) is an aggressive form of non-Hodgkins B-cell lymphoma that is endemic in Africa and sporadic in other parts of the world. It is usually diagnosed in children and young adults but rarely in middle-aged adults. The endemic form typically involves the mandible, maxilla, and abdomen. BL of orofacial region typically occurs in the jaw bones associated with tooth Metergoline mobility, dental pain and jaw expansion. Gpc3 Sudden and unexpected development of life threatening complications such as airway and abdominal obstruction and acute renal failure has been reported with BL[2]. In contrast, the sporadic form commonly presents as an abdominal mass involving the mesenteric lymph nodes or ileocecal Metergoline region. Jaw involvement occurs in only a small number of sporadic cases[3]. A wide range of local and systemic lesions may manifest in the form of gingival enlargements. The most common cause occurs secondary to prolonged exposure to dental plaque resulting as a consequence of poor oral hygiene[4]. Other causes include drug induced enlargement; conditioned enlargements secondary to pregnancy, puberty, vitamin C deficiency; idiopathic enlargements and those associated with chronic microbial infections. While majority of the causes are benign and non-neoplastic in nature, malignant neoplasms also at time manifest in the form of gingival enlargements. Gingival enlargement is Metergoline an important manifestation of malignancies like leukemia and lymphoma encountered by a dental specialist[5]. In the oral cavity lymphomas of the NHL type occurs as a primary disease or in conjunction with disseminated disease. All the variants of NHL occur in older patients except BL which usually occurs in children. The patient may present with nonspecific pain parasthesia, bony swelling with eventual perforation and soft tissue enlargement[6]. The present article reports a sporadic form Metergoline of BL in an imuunocompetent adult male manifesting with atypical clinical presentation primarily involving the oral soft tissue. == CASE REPORT == A 38-year-old male patient reported to Oral Pathology clinic at our center for evaluation of an oral mass. Patients chief complaint was painful swelling in the anterior gingiva with difficulty in eating. He noticed the swelling 6 mo back in the upper anterior gingiva which progressively increased in size and gradually involved the entire gingiva of both the arches. Patient visited a local dentist and oral prophylaxis was performed. No clinical changes were evident post prophylaxis and the lesion attained the present size within seven days. The patients medical and dental history was insignificant. Personal history included regular tobacco chewing along with lime 5-6 times a day for the.