Both systems utilize the antibody homophilicity. in the immune homeostasis and protection against pathogens (16). B1 cells in mice produce natural antibodies (7,8). In human, CD20+CD27+CD43+memory B Morroniside cells were recently identified as murine B1 counterpart (9). Natural antibodies are the important components of the Morroniside therapeutic intravenous immunoglobulin (IVIG) (1012) that is widely used […]