First, we did not analyze the relationship between serum Zn levels and disease, nor between total IgE/specific IgE levels and disease

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First, we did not analyze the relationship between serum Zn levels and disease, nor between total IgE/specific IgE levels and disease. showed comparable results (38.4, 20.6 and 4.7%, respectively), and in both groups 44.6% of patients showed increased serum total IgE levels. Table 1 Baseline and clinical characteristics of the study population. and dog-specific IgE levels increased significantly (model 2: valueon the skin surface were both increased in DS-mice. In a study of children with atopic dermatitis, Zn supplementation for 8 weeks resulted in a significant increase in Zn levels in hair, and significant reductions in eczema area severity index, transepidermal water loss and visual analogue scales for pruritus when compared to healthy control subjects7. In a randomized, placebo-controlled trial in children with asthma, GSK1838705A significant improvement in clinical symptoms and spirometry parameters was also observed in Zn supplementation groups14. The exact role of Zn in allergic diseases remains unclear. Zn affects many aspects of immune system function, and is involved in FcRI-induced mast cell activation4. FcRI stimulation has been reported to trigger microtubular formation in a calcium-independent manner23. Zn has been shown to be involved in multiple GSK1838705A actions of FcRI-induced mast cell activation, and is required for degranulation and cytokine production4. Additionally, a complex conversation between Zn, cyclic nucleotide and nitric oxide signaling, inhibitors of B kinase and inhibition of IL-1 receptor-associated kinase-1 counteracts the production of proinflammatory cytokines24. In light of these findings, Zn released from human mast cells may play a role in the regulation of the inflammation in allergic diseases. Our study has several limitations. First, we GSK1838705A did not analyze the relationship between serum Zn levels and disease, nor between total IgE/specific IgE levels and disease. Second, it remains unclear whether a single measurement of serum Zn levels accurately represents actual Zn status in the general population, and our analyses were Rabbit Polyclonal to CXCR3 not able to analyze causal relationships because of their cross-sectional nature. Prospectively designed studies are necessary to clarify the relationship between serum Zn levels and subsequent allergic sensitization. In spite of these limitations, this study has strength in its use of a comprehensive national database to represent the total Korean population, and in being the first to assess the association between serum Zn levels and allergic sensitization. In conclusion, our findings exhibited that increased total and allergen-specific IgE levels are significantly associated with decreased Zn levels. Future studies should clarify the role of Zn in the development of allergic sensitization. GSK1838705A Acknowledgements This study was supported by a National Research GSK1838705A Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2015R1C1A2A01054767). Author Contributions H.M.S., Y.H.K., and J.H.L. wrote the main manuscript. H.M.S. and J.H.L. prepared Figures 1,?2 and Tables 1,?2. J.S.K., Y.M.P., and J.Y.L. reviewed the manuscript. Notes Competing Interests The authors declare that they have no competing interests. Footnotes Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations..