Furthermore, in T2-high asthma IL-5 induces eosinophil adhesion to and migration in the extracellular matrix simply by favoring the relationship of eosinophils with periostin, a matricellular proteins whose enhanced appearance is connected with eosinophil trafficking toward bronchi (Johansson, 2017). (Hammad and Lambrecht, 2015). IL-5 discharge from ILC2 would depend on GATA3 activation induced by epithelial […]