Each function was then tested against the affinity changes of a first set of 11 A6 TCR mutants, and evaluated by correlation. to the BC1 TCR focusing on the HLA-A2 restricted NY-ESO-1157C165 cancer-testis epitope. Fifty-four percent of the designed sequence replacements exhibited XL019 improved pMHC binding as compared to the native TCR, with up to […]