Scale pub?= 20 m. EGFR in?vitro and SPTAN1 in keratinocytes in an EGF-dependent, integrin-independent manner and that formation of this complex is required for EGF-dependent migration. We further show that kindlin-1 functions to protect EGFR from lysosomal-mediated degradation. This shows a new part for kindlin-1 that has implications for understanding Kindler syndrome disease pathology. gene, […]
Independent of it is kinase activity, the TGF-activated kinase 1 (TAK1) mediates LMP1 signaling complex formation, NEMO ubiquitination and subsequent IKK2 activation. activity assays were performed. JNK activation by LMP1 was substantially reduced in all three knockout mice64. The lymphoblastoid cell line LCL 1C3 (provided by J. Mautner) was generated by infection of primary human […]