In eukaryotic DNA, cytosine is certainly methylated and changed into 5-methylcytosine by DNA methyltransferases (DNMTs) [16]. You can find three enzymatically active DNMTs in human cells: DNMT1, 3a and 3b [17C19]. lung tumor. Combos of HDACi and DNMTi with chemotherapies involve some efficiency but tend to be tied to increased toxicities. Preclinical data and scientific […]