We additional demonstrate that LXR regulates -synuclein expression and 27-OHC raises LXR-mediated -synuclein transcription positively. TH manifestation, an impact reversed from the ER agonist estradiol. We also display that 27-OHC as well as the LXR agonist GW3965 boost -synuclein as the LXR antagonist ECHS considerably attenuated the 27-OHC-induced upsurge in -synuclein manifestation. We additional demonstrate […]