For example, macrophages activated with lipopolysaccharide (LPS) undergo metabolic changes toward glycolysis, whereas macrophages activated with IL-4 commit to oxidative phosphorylation (OXPHOS) (13, 14), and both suggest that metabolic adaptation during macrophage activation is a key component of macrophage polarization, instrumental to their function in inflammation and tissue repair. Results IL-10Cdeficient macrophages exhibit altered metabolic […]