Furthermore, it is inevitable that the patients baseline status in included studies were different, such as age, menopausal status, tumor type, tumor size, lymph node status, the immunohistochemical marker for MVD detecting and duration of follow-up. (HR?=?1.79, 95% CIs 1.31C2.44, hazard ratio, confidence intervals, not available, overall survival, disease-free survival/progress-free survival/metastasis-free survival/recurrence-free survival Association of MVD and OS of cervical cancer The pooled HR for the 11 studies assessing the association between MVD and cervical cancer with OS was 1.7 (95% CIs 1.31C2.44, random-effects, Fig.?2), suggesting that high MVD level was associated with a poor prognosis of overall survival in cervical cancer patients. Since the heterogeneity among studies was significant em (I /em 2?=?60.7%, em P /em ?=?0.003), random-effects model was applied for statistical analysis. Meanwhile, subgroup meta-analysis according types of antibodies and population was conducted to evaluate the possible source of heterogeneity among these studies (Figs.?3 and ?and44). Open in a separate window Fig.?2 The forest plot assesses the association between MVD and cervical cancer with OS Open in a separate window Fig.?3 Subgroup analysis of association between count of MVD and prognosis of cervical cancer with OS detected by different antibodies Open in a separate window Fig.?4 Subgroup analysis of association between count of MVD and prognosis of cervical cancer with OS in different populations In the subgroup analysis by different antibodies, the prognostic value of MVD for OS was significant in the anti-factor VIII subgroup (HR?=?2.34, 95% CIs 1.75C3.12, em I /em 2?=?0%, n?=?5), while there was not statistically significant association in CD31 subgroup (HR?=?1.33, 95% CIs 0.65C2.72, em I /em 2?=?81.2%, n?=?4), CD34 subgroup (HR?=?1.11, 95% CIs 0.63C1.97, n?=?1) and CD105 subgroup (HR?=?1.89, 95% CIs 0.99C3.62, em I /em 2?=?0%, n?=?2). There was another subgroup about source regions of included studies, a pooled HR was 1.93 (95% CIs 1.53C2.44, em I /em 2?=?4.8%, Rabbit polyclonal to Amyloid beta A4.APP a cell surface receptor that influences neurite growth, neuronal adhesion and axonogenesis.Cleaved by secretases to form a number of peptides, some of which bind to the acetyltransferase complex Fe65/TIP60 to promote transcriptional activation.The A n?=?6) in Europe population, indicating a significantly poorer survival in cervical cancer patients with higher MVD in European countries. However, MVD level was not significantly associated with OS in Asia (HR?=?2.01, 95% CIs 0.94C4.31, em I /em 2?=?60.1%, n?=?3) and American locations (HR?=?1.17, 95% CIs 0.37C3.69, em I /em 2?=?85.5%, n?=?3). Association of MVD and DFS of cervical cancer We analyzed the relationship between the level of MVD and DFS among cervical cancer patients. There was no heterogeneity of data ( em I /em 2?=?0%), in which a fixed-effect model was selected to assess the pooled outcome (Fig.?5). As a result, MVD level was associated with a worse DFS of cervical cancer patients (HR?=?1.47, 95% CIs 1.13C1.80, n?=?6). Open in a separate window Fig.?5 The forest TW-37 plot illustrates the association between MVD and DFS of cervical cancer Furthermore, subgroup analyses based on antibody and region were used to explore the influencing factors which may impacted the overall outcomes (Figs.?6 and ?and7).7). Divided by different immunohistochemical biomarkers among the TW-37 subgroups, anti-factor VIII antibody (HR?=?1.60, 95% CIs 1.16C2.03, em I /em 2?=?0, n?=?3) showed the significantly negative association between MVD and DFS among cervical cancer patients, but not in CD34 subgroup (HR?=?1.23, 95% CIs 0.71C1.75, em I /em 2?=?8.4%, n?=?2). Open in a separate window Fig.?6 Subgroup analysis of association between count of MVD and prognosis of cervical cancer with DFS detected by different antibodies Open in a separate window Fig.?7 Subgroup analysis of association between count of MVD and prognosis of cervical cancer with DFS in different populations In addition, the included studies were stratified into the three regional distribution of patients (Europe, Asia and America). Negative effected of MVD on DFS in European countries were found TW-37 in patients with cervical cancer (HR?=?1.63, 95% CIs 1.20C2.06, em I /em 2?=?0%, n?=?4), but not in Asia location (HR?=?1.47, 95% CIs 1.13C1.80, em I /em 2?=?0%, n?=?2). Sensitivity analysis In sensitivity analysis, the leave-one-out method was applied to assess the stability of the pooled outcomes. Eligible studies were sequentially removed one by one to evaluate the influence of each included study on the.
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